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Adverse effects may be seen between lamictal and the following drugs depakote divalproex sodium , depakene valproic acid , tegretol carbamazepine , zoloft sertraline , phenobarbital and primadone, alcohol, and oral contraceptives.

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Patientstheir caregiversand families should be informed that AEDs increase the risk of suicidal thoughts and behavior and should be advised of the need to be alert for the emergence or worsening of the signs and symptoms of depressionany unusual changes in mood or behavioror the emergence of suicidal thoughtsbehavioror thoughts about self-harmBehaviors of concern should be reported immediately to healthcare providers.

Urinary frequencyacute urinary retentionoliguria with elevated blood pressureazotemiarenal failureand impotenceAlbuminuriaglycosuriaelevated BUNand microscopic deposits in the urine have also been reportedThere have been rare reports of impaired male fertility and/or abnormal spermatogenesis.

Dialysis is indicated only in severe poisoning associated with renal failureReplacement transfusion is indicated in severe poisoning in small children.

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