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Concurrent administration of ZETIA with a specific statin or fenofibrate should be in accordance with the product labeling for that medication.

For High CholesterolCombining the Zetia with low dose Atorvastatin has produced good results with my cholesterol numbersMy Cardiologist added it to my regimen about 4 years ago and it has not added any side effects other than in the wallet

Caution should be exercised when using ZETIA and cyclosporine concomitantly due to increased exposure to both ezetimibe and cyclosporineCyclosporine concentrations should be monitored in patients receiving ZETIA and cyclosporine.

From this studyit may be concluded that addition of ezetimibe has incremental effects on LDL cholesterol reductionIn patients with a high risk of hepatic insufficiencythe addition of ezetimibe to the lowest dose of lovastatin may be helpful in preventing adverse effects of high-dose lovastatin while gaining the full benefits of high-dose lovastatinAlsothe combination of ezetimibe and lovastatin has no greater adverse effects than lovastatin monotherapy7

No evidence of mutagenicity was observed in vitro in a microbial mutagenicityAmestest with Salmonella typhimurium and Escherichia coli with or without metabolic activationNo evidence of clastogenicity was observed in vitro in a chromosomal aberration assay in human peripheral blood lymphocytes with or without metabolic activationIn additionthere was no evidence of genotoxicity in the in vivo mouse micronucleus test.

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